Objective evidence for the use of polylactic acid implants in HIV-associated facial lipoatrophy using three-dimensional surface laser scanning and psychological assessment
Identifieur interne : 001C64 ( Main/Exploration ); précédent : 001C63; suivant : 001C65Objective evidence for the use of polylactic acid implants in HIV-associated facial lipoatrophy using three-dimensional surface laser scanning and psychological assessment
Auteurs : J. Ong [Royaume-Uni] ; A. Clarke [Royaume-Uni] ; P. White [Royaume-Uni] ; M. A. Johnson [Royaume-Uni] ; S. Withey [Royaume-Uni] ; P. E. M. Butler [Royaume-Uni]Source :
- Journal of plastic, reconstructive & aesthetic surgery [ 1748-6815 ] ; 2009.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Chirurgie, Psychologie.
English descriptors
- KwdEn :
Abstract
The advent of highly active antiretroviral therapy (HAART) has dramatically improved the life expectancy of people infected with human immunodeficiency virus (HIV). Although patients often have excellent disease control with these combinations of antiretrovirals, they are at risk for the multiple toxicities associated with these drugs. Facial lipoatrophy is a particularly distressing complication of some HAART regimes. This disfigurement can Lead to significant psychosocial stress, resulting in decreased treatment compliance. Polylactic acid (PLA) facial implants provide a potential method of restoring a normal appearance. One hundred consecutive patients had a course of PLA facial implants. All patients were assessed clinically and had photographs, facial surface laser scans and completed psychological questionnaires throughout the course of treatment. After a mean of 4.85 treatments per patient, there were improvements in all measures. The mean clinical scores improved from a moderate-severe grade to none-mild grade aftertreatment. Three-dimensional (3D) laser surface scans showed a volume increase of 2.81 cc overthe treated area of the cheek. There were significant improvements in all of the psychological measures. This study shows clear objective evidence of the psychological and physical benefit of PLA implants in HIV-associated facial lipodystrophy.
Affiliations:
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Ong</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Plastic and Reconstructive Surgery, The Royal Free Hospital Hampstead NHS Trust, Pond Street</s1><s2>London, NW3 2QG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>London, NW3 2QG</wicri:noRegion></affiliation></author><author><name sortKey="Clarke, A" sort="Clarke, A" uniqKey="Clarke A" first="A." last="Clarke">A. Clarke</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Plastic and Reconstructive Surgery, The Royal Free Hospital Hampstead NHS Trust, Pond Street</s1><s2>London, NW3 2QG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>London, NW3 2QG</wicri:noRegion></affiliation></author><author><name sortKey="White, P" sort="White, P" uniqKey="White P" first="P." last="White">P. White</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Statistics, University of the West of England, Frenchay Campus, Coldharbour Lane</s1><s2>Bristol, BS16 1QY</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Bristol, BS16 1QY</wicri:noRegion></affiliation></author><author><name sortKey="Johnson, M A" sort="Johnson, M A" uniqKey="Johnson M" first="M. A." last="Johnson">M. A. Johnson</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Infectious Diseases and HIV Medicine, The Royal Free Hospital Hampstead NHS Trust, Pond Street</s1><s2>London, NW3 2QG</s2><s3>GBR</s3><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>London, NW3 2QG</wicri:noRegion></affiliation></author><author><name sortKey="Withey, S" sort="Withey, S" uniqKey="Withey S" first="S." last="Withey">S. Withey</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Plastic and Reconstructive Surgery, The Royal Free Hospital Hampstead NHS Trust, Pond Street</s1><s2>London, NW3 2QG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>London, NW3 2QG</wicri:noRegion></affiliation></author><author><name sortKey="Butler, P E M" sort="Butler, P E M" uniqKey="Butler P" first="P. E. M." last="Butler">P. E. M. Butler</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Plastic and Reconstructive Surgery, The Royal Free Hospital Hampstead NHS Trust, Pond Street</s1><s2>London, NW3 2QG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>London, NW3 2QG</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of plastic, reconstructive & aesthetic surgery </title><idno type="ISSN">1748-6815</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of plastic, reconstructive & aesthetic surgery </title><idno type="ISSN">1748-6815</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term><term>Face</term><term>Human immunodeficiency virus</term><term>Implant</term><term>Lactic acid polymer</term><term>Laser</term><term>Lipoatrophy</term><term>Psychology</term><term>Surface</term><term>Surgery</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>SIDA</term><term>Lipoatrophie</term><term>Chirurgie</term><term>Lactique acide polymère</term><term>Implant</term><term>Face</term><term>Virus immunodéficience humaine</term><term>Surface</term><term>Laser</term><term>Psychologie</term><term>Traitement</term><term>Acide polylactique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Chirurgie</term><term>Psychologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The advent of highly active antiretroviral therapy (HAART) has dramatically improved the life expectancy of people infected with human immunodeficiency virus (HIV). Although patients often have excellent disease control with these combinations of antiretrovirals, they are at risk for the multiple toxicities associated with these drugs. Facial lipoatrophy is a particularly distressing complication of some HAART regimes. This disfigurement can Lead to significant psychosocial stress, resulting in decreased treatment compliance. Polylactic acid (PLA) facial implants provide a potential method of restoring a normal appearance. One hundred consecutive patients had a course of PLA facial implants. All patients were assessed clinically and had photographs, facial surface laser scans and completed psychological questionnaires throughout the course of treatment. After a mean of 4.85 treatments per patient, there were improvements in all measures. The mean clinical scores improved from a moderate-severe grade to none-mild grade aftertreatment. Three-dimensional (3D) laser surface scans showed a volume increase of 2.81 cc overthe treated area of the cheek. There were significant improvements in all of the psychological measures. This study shows clear objective evidence of the psychological and physical benefit of PLA implants in HIV-associated facial lipodystrophy.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Ong, J" sort="Ong, J" uniqKey="Ong J" first="J." last="Ong">J. Ong</name></noRegion><name sortKey="Butler, P E M" sort="Butler, P E M" uniqKey="Butler P" first="P. E. M." last="Butler">P. E. M. Butler</name><name sortKey="Clarke, A" sort="Clarke, A" uniqKey="Clarke A" first="A." last="Clarke">A. Clarke</name><name sortKey="Johnson, M A" sort="Johnson, M A" uniqKey="Johnson M" first="M. A." last="Johnson">M. A. Johnson</name><name sortKey="White, P" sort="White, P" uniqKey="White P" first="P." last="White">P. White</name><name sortKey="Withey, S" sort="Withey, S" uniqKey="Withey S" first="S." last="Withey">S. 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